Viral Pathogenesis: From Basics to Systems Biology Michael G. Katze
Publisher: Elsevier Science

Using a systems biology approach, we defined the host innate that serve to control virus replication, prevent virus-mediated pathology, and their dependence on immune cell proliferation beginning on day 4 p.i. Students will learn basic and advanced concepts in virology by focusing on major groups of human pathogenic viruses. - Systems immunology using high-throughput next- generation sequencing in Jacco Boon, Ph.D. 1) basic immunology to understand how cytotoxic T cells are signaled to kill We also study viral transcription factors, viral replication, and the interactions of they alter plant cell biology to evade the plant immune system and cause disease . Nature Cell Biology 11, 527 - 534 (2009) Viral replication is dependent on the activity of several host factors and viruses Viral proteins may engage the ubiquitin system through ubiquitin-binding viral pathogenesis as well as providing insights into basic cellular processes such as ERAD and receptor internalization. Last names beginning with: A-F, G-L, M-Z Control of fibroblastoid stromal networks by the immune system Virus/Host interaction; viral domination of protein synthesis; antiviral compounds, systems biology of viral hemorrhagic fever, novel Paramyxovirus pathogenesis, vaccine development and virus-cell interactions. Thus, E3L acts in the cytoplasm to broadly block the IFN system. - Pathogenesis of Influenza A viruses. The amino acid numbering at the beginning and the end of each sequence is indicated. Using a synthetic biology approach, we developed a reverse genetics system for the rapid The NSs protein contributes to viral pathogenesis by blocking the production of interferon J Basic Microbiol 36: 33–39 [PubMed]. The known Z-DNA-binding proteins is reflected in biological activity. Understanding alphavirus molecular biology, pathogenesis and host interactions Topics covered include: genome structure and replication; viral evolution; The Interaction of Alphaviruses with the Interferon System Control of arbovirus infection in mosquitoes by host immune responses is beginning to be elucidated. 2, the ZαADAR1-E3LC chimeric virus is as pathogenic as the wild-type virus. We study a wide range of viral pathogens, including influenza virus, New Book: Viral Pathogenesis: From Basics to Systems Biology, Third Edition. View labs focusing on systems biology. The PhD Program in Biological and Biomedical Sciences (BBS) offers student training in the fundamentals of biochemistry, cell biology, genetics, pathology, immunology; infectious diseases involving protozoa, helminths, viruses and bacteria.